dabigatran) due to the increased risk of bleeding. Use of anticoagulant such as warfarin or a direct oral anticoagulant (e.g.This is in order to obtain a muscle tissue sample in a person more severely affected with myotonic dystrophy. Known CTG repeat expansion size less than 100 repeats, unless there are clear cut signs of limb weakness and muscle wasting.Approximately 10 patients at each site will undergo the muscle biopsy.Įxclusion criteria for 95 participants in the muscle biopsy sub-study: Of the 95 patients undergoing the tibialis anterior muscle biopsy, at least half will have at least moderate weakness of ankle dorsiflexion, defined as MRC score ≤ 4+.Inclusion criteria for participants in the muscle biopsy sub-study: Note: non-ambulatory participants are not excluded, but are limited to Concurrent medical condition that would, in the opinion of the investigator or clinical evaluator, compromise performance on study measures.Concurrent pregnancy or planned pregnancy during the course of the study.Concurrent enrollment in clinical trial for DM1, or participation in trial within 6 months of entry.
#Dm1 colorado skin
Symptomatic renal or liver disease, uncontrolled diabetes or thyroid disorder, or active malignancy other than skin cancer.
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